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*Tanacetum parthenium*, a perennial herb in the Asteraceae family, is native to the Balkan Peninsula and cultivated globally. Characterized by daisy-like flowers and bitter leaves, it was traditionally used for fevers and pain. Its primary modern use is for migraine prevention. The key active compounds are sesquiterpene lactones, mainly parthenolide, which provide anti-inflammatory and vascular-regulating effects central to its medicinal efficacy.
For migraine prophylaxis, take 100-125 mg of dried leaf powder or a standardized extract (0.2% parthenolide) once daily. It is a preventative, requiring long-term, consistent use (several months), not for acute treatment. Tincture dosage is 1-4 mL, 2-3 times daily. Do not exceed 200 mg of dried herb daily. Discontinuation must be gradual to avoid rebound headaches.
Side effects include mouth ulcers and digestive upset (nausea, diarrhea), especially from fresh leaves. Avoid if pregnant or breastfeeding (potential uterine contractions). It interacts with blood-thinning medications (anticoagulants) and NSAIDs, increasing bleeding risk. Avoid if allergic to the Asteraceae family (daisies, ragweed). Gradual discontinuation is essential to prevent 'post-feverfew syndrome'.
Mediterranean
⚠️ This information is for educational purposes only. Consult your healthcare provider before using any remedy, especially if you are pregnant, nursing, taking medications, or have a medical condition.